# Derlin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5262653](https://www.wikidata.org/wiki/Q5262653)  
**Source**: https://4ort.xyz/entity/derlin-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9BUN8)
3. Q20641742
4. [The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
5. [A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
6. [Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP 1u](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
7. [UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
8. [Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
9. [USP14 inhibits ER-associated degradation via interaction with IRE1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
10. [Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
11. [Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
12. [BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
13. [Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
14. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
15. [A membrane protein required for dislocation of misfolded proteins from the ER](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
16. [RNF185 Is a Novel E3 Ligase of Endoplasmic Reticulum-associated Degradation (ERAD) That Targets Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
17. [Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
18. [Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BUN8&geneProductId=UniProtKB:Q9BUN8)
21. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BUN8&geneProductId=UniProtKB:Q9BUN8)
22. [Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
23. [Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
24. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
25. [Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
26. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8)
27. Ensembl Release 99
28. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
29. Transporter Classification database