# Damage specific DNA binding protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21108214](https://www.wikidata.org/wiki/Q21108214)  
**Source**: https://4ort.xyz/entity/damage-specific-dna-binding-protein-1


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL468)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q16531)
4. Q20641742
5. [Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
7. [Identification of a Primary Target of Thalidomide Teratogenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
8. [Selective degradation of splicing factor CAPERα by anticancer sulfonamides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
9. [The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
10. [Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
11. [Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
12. [A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
13. [SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
14. [CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
15. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
16. [Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
17. [Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
18. [DDB, a Putative DNA Repair Protein, Can Function as a Transcriptional Partner of E2F1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
19. [Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
20. [VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
21. [Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
22. [The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
23. [HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
24. [Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
25. [The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
26. [Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
27. [RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
28. [Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
29. [CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
30. [Viral immune modulators perturb the human molecular network by common and unique strategies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
31. [HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
32. [The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
33. [A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
34. [INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
35. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
36. [Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
37. [Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
38. [Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16531&geneProductId=UniProtKB:Q16531)
39. [Monoubiquitinated Histone H2A Destabilizes Photolesion-containing Nucleosomes with Concomitant Release of UV-damaged DNA-binding Protein E3 Ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16531&geneProductId=UniProtKB:Q16531)
40. [Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16531&geneProductId=UniProtKB:Q16531)
41. [Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
42. [Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
43. [Monoubiquitinated Histone H2A Destabilizes Photolesion-containing Nucleosomes with Concomitant Release of UV-damaged DNA-binding Protein E3 Ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
44. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
45. [The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
46. [DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
47. [CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
48. [PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
49. [Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531)
50. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16531&geneProductId=UniProtKB:Q16531)