# cytotoxic T-lymphocyte associated protein 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2907609](https://www.wikidata.org/wiki/Q2907609)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Cytotoxic_T-lymphocyte_associated_protein_4)  
**Source**: https://4ort.xyz/entity/cytotoxic-t-lymphocyte-associated-protein-4


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1789844)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P16410)
4. Q20641742
5. Freebase Data Dumps. 2013
6. [CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
7. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
8. [Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
9. [Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
10. [A secreted protein microarray platform for extracellular protein interaction discovery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
11. [PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
12. [Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
13. [Structural basis for co-stimulation by the human CTLA-4/B7-2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
14. [Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
16. [Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
17. [Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
18. [Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
19. [Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
21. [ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410)
22. Ensembl Release 99
23. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)