# cytochrome P450 family 3 subfamily A member 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q424440](https://www.wikidata.org/wiki/Q424440)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/CYP3A4)  
**Source**: https://4ort.xyz/entity/cytochrome-p450-family-3-subfamily-a-member-4


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08684)
4. [Swiss-Prot](http://www.uniprot.org/uniprot/P08684.txt?version=182)
5. Q20641742
6. Freebase Data Dumps. 2013
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
8. [The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
9. [Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
10. [Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
11. [CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
12. [Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
13. [Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
14. [Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
15. [Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
16. [Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
17. [Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
18. [Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
19. [Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
20. [Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
21. [An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
22. [Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684)
23. ensembl Release 95
24. Identifiers.org
25. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)