cytochrome P450 family 27 subfamily B member 1
type: Thing
alternate name: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
alternate name: 25-hydroxyvitamin D(3) 1-alpha-hydroxylase
alternate name: cytochrome P450VD1-alpha
alternate name: VD3 1A hydroxylase
alternate name: cytochrome P450 subfamily XXVIIB polypeptide 1
alternate name: CYP27B1
alternate name: cytochrome p450 27B1
alternate name: 25 hydroxyvitamin D3-1-alpha hydroxylase
alternate name: 1alpha(OH)ase
alternate name: calcidiol 1-monooxygenase
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O15528
additional property: PropertyValue
  property ID: P361
  value: cytochrome P450 superfamily
additional property: PropertyValue
  property ID: P361
  value: cytochrome P450, E-class, group I
additional property: PropertyValue
  property ID: P361
  value: cytochrome P450, conserved site, protein family
additional property: PropertyValue
  property ID: P486
  value: D015090
additional property: PropertyValue
  property ID: P527
  value: cytochrome P450, conserved site
additional property: PropertyValue
  property ID: P591
  value: 1.14.15.18
additional property: PropertyValue
  property ID: P637
  value: NP_000776
additional property: PropertyValue
  property ID: P646
  value: /m/02q865h
additional property: PropertyValue
  property ID: P672
  value: D08.244.453.499.500
additional property: PropertyValue
  property ID: P672
  value: D08.244.453.915.400
additional property: PropertyValue
  property ID: P672
  value: D08.811.682.690.708.170.493.500
additional property: PropertyValue
  property ID: P680
  value: iron ion binding
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P680
  value: monooxygenase activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: mitochondrial membranes
additional property: PropertyValue
  property ID: P682
  value: bone mineralization
additional property: PropertyValue
  property ID: P682
  value: response to vitamin D
additional property: PropertyValue
  property ID: P682
  value: calcium ion homeostasis
additional property: PropertyValue
  property ID: P702
  value: CYP27B1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000228606
additional property: PropertyValue
  property ID: P705
  value: ENSP00000449472
additional property: PropertyValue
  property ID: P705
  value: ENSP00000476959
additional property: PropertyValue
  property ID: P2892
  value: C0000340
additional property: PropertyValue
  property ID: P6366
  value: 97384784
confidence:
  popularity graph score:
    score: 0.011
    score pct: 1
    tier: established
    components:
      sitelinks: 10
      sitelinks norm: 0.024
      unique citations: 17
      unique citations norm: 0.007
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 10
  unique citations: 17
  monthly pageviews: 0
  yearly pageviews: 163
  pageview trend:
    m: 2026-06
    v: 128
  pageview trend:
    m: 2026-05
    v: 6
  pageview trend:
    m: 2026-05
    v: 2
  pageview trend:
    m: 2026-05
    v: 3
  pageview trend:
    m: 2026-04
    v: 4
  pageview trend:
    m: 2026-04
    v: 20
  popularity:
    sitelinks: 10
    max: 423
    pct: 2.4
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: O15528
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797511
    source count: 1
    confidence: 0.2
    value label: cytochrome P450 superfamily
  P361:
    value: Q24741990
    source count: 1
    confidence: 0.2
    value label: cytochrome P450, E-class, group I
  P361:
    value: Q95352863
    source count: 1
    confidence: 0.2
    value label: cytochrome P450, conserved site, protein family
  P486:
    value: D015090
    source count: 0
    confidence: 0.0
  P527:
    value: Q24724586
    source count: 1
    confidence: 0.2
    value label: cytochrome P450, conserved site
  P591:
    value: 1.14.15.18
    source count: 1
    confidence: 0.2
  P637:
    value: NP_000776
    source count: 1
    confidence: 0.2
  P646:
    value: /m/02q865h
    source count: 0
    confidence: 0.0
  P672:
    value: D08.244.453.499.500
    source count: 0
    confidence: 0.0
  P672:
    value: D08.244.453.915.400
    source count: 0
    confidence: 0.0
  P672:
    value: D08.811.682.690.708.170.493.500
    source count: 0
    confidence: 0.0
  P672:
    value: D08.811.682.690.708.170.915.400
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.422.220.453.499.500
    source count: 0
    confidence: 0.0

value: Q14358439
source count: 1
confidence: 0.2
value label: iron ion binding

value: Q13667380
source count: 1
confidence: 0.2
value label: metal ion binding

value: Q14358814
source count: 1
confidence: 0.2
value label: monooxygenase activity

value: Q14358516
source count: 1
confidence: 0.2
value label: heme binding

value: Q14358843
source count: 1
confidence: 0.2
value label: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

value: Q79899
source count: 2
confidence: 0.4
value label: cytoplasm

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q14860954
source count: 1
confidence: 0.2
value label: mitochondrial membranes

value: Q14330611
source count: 1
confidence: 0.2
value label: mitochondrial outer membrane

value: Q39572
source count: 3
confidence: 0.6
value label: mitochondrion

value: Q14599693
source count: 1
confidence: 0.2
value label: bone mineralization

value: Q14599705
source count: 2
confidence: 0.4
value label: response to vitamin D

value: Q14599743
source count: 1
confidence: 0.2
value label: calcium ion homeostasis

value: Q14599709
source count: 1
confidence: 0.2
value label: response to interferon-gamma

value: Q14599717
source count: 2
confidence: 0.4
value label: vitamin D metabolic process

value: Q14599754
source count: 1
confidence: 0.2
value label: CYP27B1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000228606
source count: 1
confidence: 0.2

value: ENSP00000449472
source count: 1
confidence: 0.2

value: ENSP00000476959
source count: 1
confidence: 0.2

value: C0000340
source count: 1
confidence: 0.2

value: 97384784
source count: 0
confidence: 0.0

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells
stated in qid: Q24306065
retrieved: 2019-04-08

source: Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3
stated in qid: Q24309233
retrieved: 2019-04-08

source: Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1
stated in qid: Q24316434
retrieved: 2019-04-08

source: 25-hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds
stated in qid: Q24299078
retrieved: 2019-04-08

source: Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain
stated in qid: Q24320314
retrieved: 2019-04-08

source: Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system
stated in qid: Q24337794
retrieved: 2019-04-08

source: The 25-Hydroxyvitamin D 1-Alpha-Hydroxylase Gene Maps to the Pseudovitamin D-Deficiency Rickets (PDDR) Disease Locus
stated in qid: Q24318580
retrieved: 2019-04-08

source: HIV-1 p17 and IFN-γ Both Induce Fructose 1,6-Bisposphatase
stated in qid: Q24308813
retrieved: 2019-04-08

source: Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion
stated in qid: Q24337517
retrieved: 2019-04-08

source: Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells
stated in qid: Q24307649
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: ENZYME
stated in qid: Q26737758
retrieved: 2019-09-09

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: UMLS 2023
stated in qid: Q118645236
retrieved: 2023-05-24

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q1149122
domain: protein
level: standard
html url: https://4ort.xyz/entity/cytochrome-p450-family-27-subfamily-b-member-1
markdown url: https://4ort.xyz/entity/cytochrome-p450-family-27-subfamily-b-member-1.md
facts url summary: https://4ort.xyz/entity/cytochrome-p450-family-27-subfamily-b-member-1/facts.json
facts url standard: https://4ort.xyz/entity/cytochrome-p450-family-27-subfamily-b-member-1/facts.json
facts url full: https://4ort.xyz/entity/cytochrome-p450-family-27-subfamily-b-member-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-13T07:10:49.925533Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-04-10T23:28:42.630679+00:00Z