# Cytochrome P450, family 17, subfamily a, polypeptide 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28563113](https://www.wikidata.org/wiki/Q28563113)  
**Source**: https://4ort.xyz/entity/cytochrome-p450-family-17-subfamily-a-polypeptide-1-q28563113


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P11715)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
5. [Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
6. [Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
8. [Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
9. [Molecular and neurochemical evidence for the biosynthesis of dehydroepiandrosterone in the adult rat spinal cord](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
10. [Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
11. [Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
12. [Absence of correlation between in situ expression of cytochrome P450 17alpha hydroxylase/lyase and 3beta-hydroxysteroid dehydrogenase/(Delta5-4) isomerase messenger ribonucleic acids and steroidogenesis during pubertal development in the rat testis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
13. [Upregulation of peripubertal rat Leydig cell steroidogenesis following 24 h in vitro and in vivo exposure to atrazine.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
14. [Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
15. [Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
16. [Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
17. [Contamination with depleted or enriched uranium differently affects steroidogenesis metabolism in rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
18. [Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di(n-butyl) phthalate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
19. [Testicular toxicity of profenofos in matured male rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
20. [Polychlorinated biphenyls have inhibitory effect on testicular steroidogenesis by downregulation of P45017α and P450scc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
21. [Temporal and anatomical sensitivities to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin leading to premature acyclicity with age in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
22. [Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
23. [Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
24. [Semicomprehensive analysis of the postnatal age-related changes in the mRNA expression of sex steroidogenic enzymes and sex steroid receptors in the male rat hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
25. [Adrenarche in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
26. [Immunolocalization of androgen receptor and steroidogenic enzymes in cumuli oophori of pre- and post-ovulatory rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
27. [Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
28. [Retinoic acid stimulates 17beta-estradiol and testosterone synthesis in rat hippocampal slice cultures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
29. [Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
30. [Exogenous granulocyte-macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
31. [The expression of serum steroid sex hormones and steroidogenic enzymes following intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
32. [An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
33. [Influence of long-term dietary administration of procymidone, a fungicide with anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
34. [Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
35. [Lipopolysaccharide directly stimulates aldosterone production via toll‐like receptor 2 and toll‐like receptor 4 related PI3K/Akt pathway in rat adrenal zona glomerulosa cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
36. [Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
37. [Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
38. [Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11715)
39. ensembl Release 106