cytochrome P450, family 1, subfamily a, polypeptide 1
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P00184
additional property: PropertyValue
  property ID: P361
  value: cytochrome P450 superfamily
additional property: PropertyValue
  property ID: P361
  value: cytochrome P450, E-class, group I, CYP1
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P527
  value: cytochrome P450, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_001129531
additional property: PropertyValue
  property ID: P637
  value: NP_034122
additional property: PropertyValue
  property ID: P680
  value: iron ion binding
additional property: PropertyValue
  property ID: P680
  value: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P681
  value: organelle membrane
additional property: PropertyValue
  property ID: P681
  value: endoplasmic reticulum membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: toxin metabolic process
additional property: PropertyValue
  property ID: P682
  value: amine metabolic process
additional property: PropertyValue
  property ID: P682
  value: dibenzo-p-dioxin metabolic process
additional property: PropertyValue
  property ID: P702
  value: Cyp1a1
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000034865
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000150277
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 16
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 16
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P00184
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797511
    source count: 1
    confidence: 0.2
    value label: cytochrome P450 superfamily
  P361:
    value: Q24738723
    source count: 1
    confidence: 0.2
    value label: cytochrome P450, E-class, group I, CYP1
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q95352863
    source count: 1
    confidence: 0.2
    value label: cytochrome P450, conserved site, protein family
  P527:
    value: Q24724586
    source count: 1
    confidence: 0.2
    value label: cytochrome P450, conserved site
  P637:
    value: NP_001129531
    source count: 1
    confidence: 0.2
  P637:
    value: NP_034122
    source count: 1
    confidence: 0.2
  P680:
    value: Q14358439
    source count: 1
    confidence: 0.2
    value label: iron ion binding
  P680:
    value: Q14864403
    source count: 2
    confidence: 0.4
    value label: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P680:
    value: Q14358516
    source count: 1
    confidence: 0.2
    value label: heme binding
  P680:
    value: Q14358843
    source count: 1
    confidence: 0.2
    value label: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
  P681:
    value: Q14878067
    source count: 1
    confidence: 0.2
    value label: organelle membrane
  P681:
    value: Q14329032
    source count: 1
    confidence: 0.2
    value label: endoplasmic reticulum membrane
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q79927
    source count: 1
    confidence: 0.2
    value label: endoplasmic reticulum
  P681:
    value: Q79899
    source count: 3
    confidence: 0.6
    value label: cytoplasm
  P682:
    value: Q14890104
    source count: 1
    confidence: 0.2
    value label: toxin metabolic process
  P682:
    value: Q14916457
    source count: 1
    confidence: 0.2
    value label: amine metabolic process
  P682:
    value: Q14890097
    source count: 1
    confidence: 0.2
    value label: dibenzo-p-dioxin metabolic process
  P682:
    value: Q14864417
    source count: 1
    confidence: 0.2
    value label: heterocycle metabolic process
  P682:
    value: Q14875833
    source count: 1
    confidence: 0.2
    value label: hydrogen peroxide biosynthetic process
  P702:
    value: Q14916462
    source count: 1
    confidence: 0.2
    value label: Cyp1a1

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000034865
source count: 1
confidence: 0.2

value: ENSMUSP00000150277
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2
stated in qid: Q28510320
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice
stated in qid: Q28504694
retrieved: 2018-04-24

source: Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice
stated in qid: Q28504694
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes
stated in qid: Q28512202
retrieved: 2019-05-09

source: Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
stated in qid: Q28592705
retrieved: 2019-05-09

source: For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential
stated in qid: Q28586157
retrieved: 2019-05-09

source: Cyp1a2 protects against reactive oxygen production in mouse liver microsomes
stated in qid: Q28507385
retrieved: 2019-05-09

source: Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate
stated in qid: Q28288804
retrieved: 2019-05-09

source: 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation
stated in qid: Q24307446
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q14916463
domain: protein
level: standard
html url: https://4ort.xyz/entity/cytochrome-p450-family-1-subfamily-a-polypeptide-1
markdown url: https://4ort.xyz/entity/cytochrome-p450-family-1-subfamily-a-polypeptide-1.md
facts url summary: https://4ort.xyz/entity/cytochrome-p450-family-1-subfamily-a-polypeptide-1/facts.json
facts url standard: https://4ort.xyz/entity/cytochrome-p450-family-1-subfamily-a-polypeptide-1/facts.json
facts url full: https://4ort.xyz/entity/cytochrome-p450-family-1-subfamily-a-polypeptide-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-08T22:46:57.005119Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:10:53.568599+00:00Z