# Cytochrome P450, family 1, subfamily a, polypeptide 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562675](https://www.wikidata.org/wiki/Q28562675)  
**Source**: https://4ort.xyz/entity/cytochrome-p450-family-1-subfamily-a-polypeptide-1-q28562675


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P00185)
3. Q20641742
4. [Inhibition by retinoids of benzo(A)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
6. [Characteristic properties of a retinoic acid synthetic cytochrome P-450 purified from liver microsomes of 3-methylcholanthrene-induced rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
7. [Biodegradation of polychlorinated dibenzo-p-dioxins by recombinant yeast expressing rat CYP1A subfamily](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
8. [Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
9. [Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
11. [Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
12. [Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
13. [Interaction of Adrenodoxin with P4501A1 and Its Truncated Form P450MT2 through Different Domains: Differential Modulation of Enzyme Activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
14. [Role of THR501 residue in substrate binding and catalytic activity of cytochrome P4501A1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
15. [The proximate carcinogen trans-3,4-dihydroxy-3,4-dihydro-dibenz[c,h]acridine is oxidized stereoselectively and regioselectively by cytochrome 1A1, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
16. [Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
17. [Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
18. [Interaction between cytochrome P450 and other drug-metabolizing enzymes: evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
19. [Accumulation of mitochondrial P450MT2, NH(2)-terminal truncated cytochrome P4501A1 in rat brain during chronic treatment with beta-naphthoflavone. A role in the metabolism of neuroactive drugs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
20. [Mechanisms of exocrine pancreatic toxicity induced by oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Harlan Sprague-Dawley Rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
21. [Targeting of NH2-terminal–processed Microsomal Protein to Mitochondria: A Novel Pathway for the Biogenesis of Hepatic Mitochondrial P450MT2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00185&geneProductId=UniProtKB:P00185)
23. [Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
24. [Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00185&geneProductId=UniProtKB:P00185)
25. [Effect of hypoxic stress on xenobiotic metabolism and activities of various isoforms of cytochrome P-450](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
26. [Developmental changes in the expression of enterocytic and hepatic cytochromes P4501A in rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
27. [Age-related changes in the mRNA levels of CYP1A1, CYP2B1/2 and CYP3A1 isoforms in rat small intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
28. [Modulation of CYP1A1 and CYP2B1 expression upon cell cycle progression in cultures of primary rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
29. [Differential regulation of cytochrome P450 isozyme mRNAs and proteins by femur fracture trauma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
30. [Cytochrome P-450 family 1 in rat embryo cell culture immortalized by Rausher leukemia virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
31. [Infection of rats with Taenia taeniformis metacestodes increases hepatic CYP450, induces the activity of CYP1A1, CYP2B1 and COH isoforms and increases the genotoxicity of the procarcinogens benzo[a]pyrene, cyclophosphamide and aflatoxin B(1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
32. [Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
33. [Increased vascular contractility in isolated vessels from cigarette smoking rats is mediated by basal endothelin release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
34. [Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
35. [In vivo effects of Urtica urens (dwarf nettle) on the expression of CYP1A in control and 3-methylcholanthrene-exposed rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
36. [Panax ginseng effects on DNA damage, CYP1A1 expression and histopathological changes in testes of rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
37. [Apoptosis and bax expression are increased by coal dust in the polycyclic aromatic hydrocarbon - exposed lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
38. [Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
39. [Influence of iron (56Fe2O3 or 54Fe2O3) in the upregulation of cytochrome P4501A1 by benzo[a]pyrene in the respiratory tract of Sprague-Dawley rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
40. [Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
41. [The effect of aspartame on rat brain xenobiotic-metabolizing enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
42. [Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of delta-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
43. [Combined effects of repeated administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated biphenyls on kidneys of male rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
44. [Strain differences in hepatic cytochrome P450 1A and 3A expression between Sprague-Dawley and Wistar rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
45. [Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
46. [Time-dependent acetylsalicylic acid effects on liver CYP1A and antioxidant enzymes in a rat model of 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
47. [Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
48. [Characterization of deltamethrin metabolism by rat plasma and liver microsomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
49. [Generation of 2,3,7,8-TCDD-metabolizing enzyme by modifying rat CYP1A1 through site-directed mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)
50. [Rat cytochrome P450-mediated transformation of dichlorodibenzo-p-dioxins by recombinant white-rot basidiomycete Coriolus hirsutus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00185)