# cytochrome P450 family 1 subfamily A member 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3737406](https://www.wikidata.org/wiki/Q3737406)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/CYP1A2)  
**Source**: https://4ort.xyz/entity/cytochrome-p450-family-1-subfamily-a-member-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05177)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
5. [Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
6. [The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
7. [Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
8. [Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
9. [Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
10. [Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177)
12. [Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177)
13. [Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177)
14. [Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
15. [Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
17. [Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05177&geneProductId=UniProtKB:P05177)
18. [Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
19. [Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05177)
20. Ensembl Release 99
21. UMLS 2023
22. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)