# cytochrome b-245 alpha chain

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109992](https://www.wikidata.org/wiki/Q21109992)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/P22phox)  
**Source**: https://4ort.xyz/entity/cytochrome-b-245-alpha-chain


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P13498)
3. Q20641742
4. [Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
6. [p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
7. [Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
8. [Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phox](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
9. [NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
10. [Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
11. [Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
12. [Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking"](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
13. [Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
14. [Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13498&geneProductId=UniProtKB:P13498)
16. [Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13498&geneProductId=UniProtKB:P13498)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13498&geneProductId=UniProtKB:P13498)
18. [Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
20. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13498&geneProductId=UniProtKB:P13498)
21. [Study of NADPH oxidase-activated sites in human neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
22. [Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13498&geneProductId=UniProtKB:P13498)
23. [Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13498&geneProductId=UniProtKB:P13498)
24. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
25. [Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13498)
26. [Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13498&geneProductId=UniProtKB:P13498)
27. Ensembl Release 99
28. Transporter Classification database
29. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)