# cystic fibrosis transmembrane conductance regulator

> mammalian protein found in Homo sapiens

**Wikidata**: [Q420470](https://www.wikidata.org/wiki/Q420470)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Cystic_fibrosis_transmembrane_conductance_regulator)  
**Source**: https://4ort.xyz/entity/cystic-fibrosis-transmembrane-conductance-regulator


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P13569)
4. ENZYME
5. Q20641742
6. Freebase Data Dumps. 2013
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
8. [A Golgi-associated PDZ Domain Protein Modulates Cystic Fibrosis Transmembrane Regulator Plasma Membrane Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
9. [SLC26A9 stimulates CFTR expression and function in human bronchial cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
10. [CFTR and TMEM16A are separate but functionally related Cl- channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
11. [Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
12. [SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
13. [The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
14. [The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
15. [The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
16. [BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
17. [Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
18. [Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
19. [Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
20. [A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
21. [The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
22. [Rescue of ΔF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
23. [Investigating CFTR and KCa3.1 Protein/Protein Interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
24. [Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
25. [Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
26. [Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
27. [Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
28. [The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
29. [Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
30. [Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
31. [CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
32. [CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
33. [A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
34. [Mechanism of direct bicarbonate transport by the CFTR anion channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
35. [Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
36. [Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
37. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)
38. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
39. [Differential function of the two nucleotide binding domains on cystic fibrosis transmembrane conductance regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
40. [ATPase activity of the cystic fibrosis transmembrane conductance regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
41. [BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13569)
42. [CFTR and TMEM16A are separate but functionally related Cl- channels](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)
43. [CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)
44. [Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)
45. [The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)
46. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)
47. [CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)
48. [Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)
49. [Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)
50. [Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13569&geneProductId=UniProtKB:P13569)