Cystic fibrosis transmembrane conductance regulator
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P26361
additional property: PropertyValue
  property ID: P361
  value: cystic fibrosis transmembrane conductance regulator
additional property: PropertyValue
  property ID: P361
  value: ABC transporter type 1, transmembrane domain superfamily
additional property: PropertyValue
  property ID: P361
  value: P-loop containing nucleoside triphosphate hydrolase
additional property: PropertyValue
  property ID: P527
  value: CFTR regulator domain
additional property: PropertyValue
  property ID: P527
  value: AAA+ ATPase domain
additional property: PropertyValue
  property ID: P527
  value: ABC transporter-like
additional property: PropertyValue
  property ID: P637
  value: NP_066388
additional property: PropertyValue
  property ID: P638
  value: 1Q3H
additional property: PropertyValue
  property ID: P638
  value: 1R0W
additional property: PropertyValue
  property ID: P638
  value: 1R0X
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: PDZ domain binding
additional property: PropertyValue
  property ID: P680
  value: chloride transmembrane transporter activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: recycling endosome
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P682
  value: positive regulation of cyclic nucleotide-gated ion channel activity
additional property: PropertyValue
  property ID: P682
  value: positive regulation of voltage-gated chloride channel activity
additional property: PropertyValue
  property ID: P682
  value: intracellular pH elevation
additional property: PropertyValue
  property ID: P702
  value: Cftr
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000049228
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000111064
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000116957
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 19
      unique citations norm: 0.007
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 19
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P26361
    source count: 1
    confidence: 0.2
  P361:
    value: Q24745449
    source count: 1
    confidence: 0.2
    value label: cystic fibrosis transmembrane conductance regulator
  P361:
    value: Q41797742
    source count: 1
    confidence: 0.2
    value label: ABC transporter type 1, transmembrane domain superfamily
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P361:
    value: Q83138448
    source count: 1
    confidence: 0.2
    value label: CFTR regulator domain, protein family
  P361:
    value: Q4649768
    source count: 1
    confidence: 0.2
    value label: AAA proteins
  P527:
    value: Q24768570
    source count: 1
    confidence: 0.2
    value label: CFTR regulator domain
  P527:
    value: Q24774001
    source count: 1
    confidence: 0.2
    value label: AAA+ ATPase domain
  P527:
    value: Q24772708
    source count: 1
    confidence: 0.2
    value label: ABC transporter-like
  P527:
    value: Q24725666
    source count: 1
    confidence: 0.2
    value label: ABC transporter, conserved site
  P527:
    value: Q24768525
    source count: 1
    confidence: 0.2
    value label: ABC transporter type 1, transmembrane domain
  P637:
    value: NP_066388
    source count: 1
    confidence: 0.2
  P638:
    value: 1Q3H
    source count: 1
    confidence: 0.2
  P638:
    value: 1R0W
    source count: 1
    confidence: 0.2
  P638:
    value: 1R0X
    source count: 1
    confidence: 0.2
  P638:
    value: 1R0Y
    source count: 1
    confidence: 0.2
  P638:
    value: 1R0Z
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14860298
    source count: 2
    confidence: 0.4
    value label: PDZ domain binding
  P680:
    value: Q14877693
    source count: 1
    confidence: 0.2
    value label: chloride transmembrane transporter activity
  P680:
    value: Q167149
    source count: 5
    confidence: 1.0
    value label: protein binding

value: Q14864707
source count: 3
confidence: 0.6
value label: chloride channel inhibitor activity

value: Q79899
source count: 2
confidence: 0.4
value label: cytoplasm

value: Q14860547
source count: 2
confidence: 0.4
value label: recycling endosome

value: Q220599
source count: 3
confidence: 0.6
value label: cytosol

value: Q824237
source count: 1
confidence: 0.2
value label: endosome

value: Q14864702
source count: 1
confidence: 0.2
value label: early endosome membrane

value: Q21172289
source count: 3
confidence: 0.6
value label: positive regulation of cyclic nucleotide-gated ion channel activity

value: Q21172290
source count: 2
confidence: 0.4
value label: positive regulation of voltage-gated chloride channel activity

value: Q21121346
source count: 1
confidence: 0.2
value label: intracellular pH elevation

value: Q14864045
source count: 1
confidence: 0.2
value label: membrane hyperpolarization

value: Q14864549
source count: 1
confidence: 0.2
value label: cholesterol transport

value: Q14864713
source count: 1
confidence: 0.2
value label: Cftr

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000049228
source count: 1
confidence: 0.2

value: ENSMUSP00000111064
source count: 1
confidence: 0.2

value: ENSMUSP00000116957
source count: 1
confidence: 0.2

value: ENSMUSP00000111065
source count: 1
confidence: 0.2

value: ENSMUSP00000115334
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation
stated in qid: Q28589082
retrieved: 2019-05-09

source: IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct
stated in qid: Q28504720
retrieved: 2019-05-09

source: Irbit Mediates Synergy Between Ca2+ and cAMP Signaling Pathways During Epithelial Transport in Mice
stated in qid: Q28594050
retrieved: 2019-05-09

source: Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone
stated in qid: Q24312937
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells
stated in qid: Q24298624
retrieved: 2019-05-09

source: Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA–regulated apical chloride channels in cortical collecting duct
stated in qid: Q28941235
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells
stated in qid: Q24298624
retrieved: 2018-07-16

source: Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis
stated in qid: Q28593455
retrieved: 2018-07-16

source: Rescue of ΔF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway
stated in qid: Q24337106
retrieved: 2019-05-09

source: Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis
stated in qid: Q28593455
retrieved: 2019-05-09

source: Altered cholesterol homeostasis in cultured and in vivo models of cystic fibrosis
stated in qid: Q28509055
retrieved: 2019-05-09

source: Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA–regulated apical chloride channels in cortical collecting duct
stated in qid: Q28941235
retrieved: 2018-07-16

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q14864718
domain: protein
level: standard
html url: https://4ort.xyz/entity/cystic-fibrosis-transmembrane-conductance-regulator-q14864718
markdown url: https://4ort.xyz/entity/cystic-fibrosis-transmembrane-conductance-regulator-q14864718.md
facts url summary: https://4ort.xyz/entity/cystic-fibrosis-transmembrane-conductance-regulator-q14864718/facts.json
facts url standard: https://4ort.xyz/entity/cystic-fibrosis-transmembrane-conductance-regulator-q14864718/facts.json
facts url full: https://4ort.xyz/entity/cystic-fibrosis-transmembrane-conductance-regulator-q14864718/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-08T09:44:26.783907Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:38:59.049836+00:00Z