# Cyclin T1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116327](https://www.wikidata.org/wiki/Q21116327)  
**Source**: https://4ort.xyz/entity/cyclin-t1-q21116327


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O60563)
3. Q20641742
4. [The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
6. [7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
8. [Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
9. [Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
10. [Identification of multiple cyclin subunits of human P-TEFb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
11. [Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
12. [MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
13. [The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
14. [Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
15. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
16. [The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
17. [LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
18. [Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
19. [Global landscape of HIV-human protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
20. [Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
21. [Human mediator subunit MED26 functions as a docking site for transcription elongation factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
22. [Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
23. [The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
24. [Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
25. [The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
26. [Crystal structure of HIV-1 Tat complexed with human P-TEFb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
27. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
28. [A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
29. [RNA polymerase II–associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
30. [RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
31. [Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
32. [BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
33. [NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
34. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60563&geneProductId=UniProtKB:O60563)
35. [A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60563&geneProductId=UniProtKB:O60563)
36. [Identification of multiple cyclin subunits of human P-TEFb](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60563&geneProductId=UniProtKB:O60563)
37. [The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60563&geneProductId=UniProtKB:O60563)
38. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60563&geneProductId=UniProtKB:O60563)
39. [A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
40. [CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563)
41. [Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60563&geneProductId=UniProtKB:O60563)
42. Ensembl Release 99