# Cyclin dependent kinase inhibitor 2A

> mammalian protein found in Mus musculus

**Wikidata**: [Q14907028](https://www.wikidata.org/wiki/Q14907028)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-inhibitor-2a


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P51480)
3. Q20641742
4. [Swiss-Prot](http://www.uniprot.org/uniprot/P51480.txt?version=139)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
6. [Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
7. [ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
8. [Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
9. [The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
11. [CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
12. [Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
13. [Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
14. [Cloning and characterization of murine p16INK4a and p15INK4b genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
15. [Structural polymorphism in the N-terminal oligomerization domain of NPM1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
16. [CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
17. [Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
18. [Cloning and characterization of murine p16INK4a and p15INK4b genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
19. [Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
20. [Structural polymorphism in the N-terminal oligomerization domain of NPM1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
21. [Defining the molecular basis of Arf and Hdm2 interactions](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
22. [Nucleophosmin is required for DNA integrity and p19Arf protein stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
23. [Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
24. [ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
25. [The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
26. [Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
27. [Nucleophosmin is required for DNA integrity and p19Arf protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
28. [Defining the molecular basis of Arf and Hdm2 interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
29. [Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
30. [p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
31. [The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
32. [Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
33. [Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
34. [Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
35. [p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
36. [Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
37. [Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
38. [A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
39. [The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
40. [c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51480&geneProductId=UniProtKB:P51480)
41. [The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
42. [Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
43. [Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
44. [p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
45. [Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
46. [Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
47. [A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
48. [The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
49. [c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51480)
50. ensembl Release 106