# Cyclin dependent kinase inhibitor 1B

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5009962](https://www.wikidata.org/wiki/Q5009962)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-inhibitor-1b


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P46527)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
6. [Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
7. [HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
8. [p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
9. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
10. [Role of T198 modification in the regulation of p27(Kip1) protein stability and function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
11. [The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
12. [Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
13. [Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
14. [14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
15. [Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
16. [Acetylation-dependent regulation of Skp2 function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
17. [Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
18. [Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
19. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
20. [Cyclin-binding motifs are essential for the function of p21CIP1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
21. [RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
22. [Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
23. [C-terminal phosphorylation controls the stability and function of p27kip1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
24. [SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
25. [New functional activities for the p21 family of CDK inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
26. [A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
27. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
28. [Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
29. [Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
30. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
31. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
32. [Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
33. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
34. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
35. [Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
36. [Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
37. [Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
38. [p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
39. [A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
40. [Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
41. [Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
42. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
43. [p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
44. [PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
45. [Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
46. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
47. [Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
48. [Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
49. [Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)
50. [Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527)