# Cyclin dependent kinase inhibitor 1A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q423686](https://www.wikidata.org/wiki/Q423686)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/P21)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-inhibitor-1a


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P38936)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
6. [A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
7. [PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
8. [Self-assembling protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
9. [HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
10. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
11. [hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
12. [CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
13. [Functional roles of p12, the fourth subunit of human DNA polymerase delta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
14. [Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
15. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
16. [Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
17. [Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
18. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
19. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
20. [Cyclin-binding motifs are essential for the function of p21CIP1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
21. [Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
22. [Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
23. [A directed protein interaction network for investigating intracellular signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
24. [Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
25. [Functional characterization of human PFTK1 as a cyclin-dependent kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
26. [Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
27. [The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
28. [New functional activities for the p21 family of CDK inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
29. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
30. [Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
31. [Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
32. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
33. [Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
34. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
35. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
36. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
37. [The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
38. [DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
39. [E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
40. [Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
41. [Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
42. [CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
43. [Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
44. [Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
45. [The cyclin-dependent kinase inhibitors p15INK4B and p21CIP1 are critical regulators of fibrillar collagen-induced tumor cell cycle arrest](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
46. [Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
47. [Feedback between p21 and reactive oxygen production is necessary for cell senescence](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
48. [Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
49. [Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)
50. [Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade](http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936)