# Cyclin dependent kinase 8

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5198254](https://www.wikidata.org/wiki/Q5198254)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-8


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49336)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
6. [Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
7. [Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
8. [The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
9. [CDK8 is a positive regulator of transcriptional elongation within the serum response network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
10. [The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
11. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
12. [HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
13. [E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
14. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
15. [Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
16. [Cyclin C is a haploinsufficient tumour suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
17. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
18. [An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
19. [A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49336&geneProductId=UniProtKB:P49336)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
22. [A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49336&geneProductId=UniProtKB:P49336)
23. [The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49336&geneProductId=UniProtKB:P49336)
24. [Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
25. [The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
26. [A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336)
27. Ensembl Release 99
28. Identifiers.org
29. UMLS 2023