# Cyclin dependent kinase 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5198252](https://www.wikidata.org/wiki/Q5198252)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-6-q5198252


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3894860)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL189963)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3301610)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL445813)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL488436)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545110)
9. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q00534)
10. Q20641742
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00534&geneProductId=UniProtKB:Q00534)
13. [Identification of G1 kinase activity for cdk6, a novel cyclin D partner](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00534&geneProductId=UniProtKB:Q00534)
14. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
15. [Interaction between Cdc37 and Cdk4 in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
16. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
17. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
18. [A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
19. [Functional characterization of human PFTK1 as a cyclin-dependent kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
20. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
21. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
22. [A p18 mutant defective in CDK6 binding in human breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
23. [Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
24. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
25. [A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
26. [Proteomic analysis of p16ink4a-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
27. [A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
28. [Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
29. [Self-assembling protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
30. [Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
31. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
32. [A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
33. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
34. [Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
35. [Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
36. [p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
37. [Identification of G1 kinase activity for cdk6, a novel cyclin D partner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
38. [Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
39. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
40. [Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
41. [CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
42. [CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
43. [The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
44. [Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00534&geneProductId=UniProtKB:Q00534)
45. [Cdk6-dependent regulation of G(1) length controls adult neurogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
46. [CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
47. [Changes in motility, gene expression and actin dynamics: Cdk6-induced cytoskeletal changes associated with differentiation in mouse astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
48. [Beyond the cell cycle: a new role for Cdk6 in differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
49. [Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)
50. [Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534)