# Cyclin-dependent kinase 5

> mammalian protein found in Mus musculus

**Wikidata**: [Q21495012](https://www.wikidata.org/wiki/Q21495012)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-5


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49615)
3. Q20641742
4. [Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
5. [Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
7. [Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
8. [Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
9. [Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
10. [Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
11. [Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
12. [Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
13. [Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
14. [Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
15. [Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
16. [A novel cdc2-related protein kinase expressed in the nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
17. [Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
18. [p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
19. [Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
20. [The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
21. [Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
22. [Puralpha is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
23. [CDK5 regulates cell adhesion and migration in corneal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
24. [Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
25. [Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
26. [CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
27. [Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49615&geneProductId=UniProtKB:P49615)
29. [Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
30. [Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
31. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
32. [Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
33. [Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49615&geneProductId=UniProtKB:P49615)
34. [Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49615&geneProductId=UniProtKB:P49615)
35. [Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49615&geneProductId=UniProtKB:P49615)
36. [Intracellular localization of cyclin-dependent kinase 5 (CDK5) in mouse neuron: CDK5 is located in both nucleus and cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49615&geneProductId=UniProtKB:P49615)
37. [A nomenclature proposal for the chromogranin/secretogranin proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
38. [A nomenclature proposal for the chromogranin/secretogranin proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49615&geneProductId=UniProtKB:P49615)
39. [CDK5 regulates cell adhesion and migration in corneal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49615&geneProductId=UniProtKB:P49615)
40. [A novel cdc2-related protein kinase expressed in the nervous system](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49615&geneProductId=UniProtKB:P49615)
41. [Intracellular localization of cyclin-dependent kinase 5 (CDK5) in mouse neuron: CDK5 is located in both nucleus and cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
42. [Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
43. [Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
44. [LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
45. [NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49615&geneProductId=UniProtKB:P49615)
46. [Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
47. [Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
48. [Cyclin-dependent kinase 5 is required for associative learning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
49. [Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)
50. [Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49615)