# Cyclin-dependent kinase 5

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28556383](https://www.wikidata.org/wiki/Q28556383)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-5-q28556383


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q03114)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
5. [Pctaire1 Interacts with p35 and Is a Novel Substrate for Cdk5/p35](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
6. [Phosphorylation of Protein Phosphatase 1 by Cyclin-dependent Protein Kinase 5 during Nerve Growth Factor-induced PC12 Cell Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
7. [Phosphorylation of FTDP-17 Mutant tau by Cyclin-dependent Kinase 5 Complexed with p35, p25, or p39](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
8. [Phosphorylation of the High Molecular Weight Neurofilament Protein (NF-H) by Cdk5 and p35](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
9. [Critical Role of CDK5 and Polo-like Kinase 2 in Homeostatic Synaptic Plasticity during Elevated Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
10. [Cyclin-dependent Kinase 5 Phosphorylates Serine 31 of Tyrosine Hydroxylase and Regulates Its Stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
11. [Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked Dopamine Receptor in Rat Brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
12. [Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
13. [Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
14. [Activation of latent cyclin‐dependent kinase 5 (Cdk5)–p35 complexes by membrane dissociation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
15. [Regulation of NMDA receptors by cyclin-dependent kinase-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
16. [Cdk5 and Trio modulate endocrine cell exocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
17. [A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
19. [The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
20. [Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
21. [A nestin scaffold links Cdk5/p35 signaling to oxidant‐induced cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
22. [Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
23. [Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
24. [c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
25. [Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
26. [Balance of Calcineurin Aα and CDK5 Activities Sets Release Probability at Nerve Terminals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
27. [Differential Roles of Nuclear and Cytoplasmic Cyclin-Dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
28. [Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
29. [p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
30. [Microtubule Association of the Neuronal p35 Activator of Cdk5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
31. [Regulation of membrane association and kinase activity of Cdk5–p35 by phosphorylation of p35](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
32. [The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the α-Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and α-Actinin-1 in a Calcium-Dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
33. [CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
34. [Inhibition of Cyclin-dependent Kinase 5 Activity Protects Pancreatic Beta Cells from Glucotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
35. [L6 myoblast differentiation is modulated by Cdk5 via the PI3K–AKT–p70S6K signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
36. [Cdk5 is essential for synaptic vesicle endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
37. [Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
38. [Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
39. [Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03114)
40. ensembl Release 106