# cyclin dependent kinase 5

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116933](https://www.wikidata.org/wiki/Q21116933)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-5-q21116933


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103840)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL445813)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL488436)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545083)
7. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q00535)
8. [Source](https://meshb.nlm.nih.gov/#/record/ui?ui=D051360)
9. Q20641742
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
11. [Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
12. [A family of human cdc2‐related protein kinases.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00535&geneProductId=UniProtKB:Q00535)
14. [A family of human cdc2‐related protein kinases.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00535&geneProductId=UniProtKB:Q00535)
15. [The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00535&geneProductId=UniProtKB:Q00535)
16. [Cyclin-Dependent Kinase 5 Modulates the Transcriptional Activity of the Mineralocorticoid Receptor and Regulates Expression of Brain-Derived Neurotrophic Factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00535&geneProductId=UniProtKB:Q00535)
17. [The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the α-Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and α-Actinin-1 in a Calcium-Dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
18. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
19. [The Protein Interaction Landscape of the Human CMGC Kinase Group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
20. [A Proteome-Scale Map of the Human Interactome Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
21. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
22. [Pooled‐matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
23. [Mechanism of CDK5/p25 Binding by CDK Inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
24. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
25. [Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
26. [Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
27. [No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
28. [Molecular Basis for the Specificity of p27 Toward Cyclin-dependent Kinases that Regulate Cell Division](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
29. [Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
30. [Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
31. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
32. [Roles of tau protein in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
33. [The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
34. [Cyclin-Dependent Kinase 5 Modulates the Transcriptional Activity of the Mineralocorticoid Receptor and Regulates Expression of Brain-Derived Neurotrophic Factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
35. [Microtubule Association of the Neuronal p35 Activator of Cdk5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
36. [Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
37. [Synaptic Vesicle Pools and Dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
38. [p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
39. [Cdk5: Multitasking between physiological and pathological conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
40. [CDK 5 protects from caspase‐induced Ataxin‐3 cleavage and neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
41. [Cdk5: Multitasking between physiological and pathological conditions](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00535&geneProductId=UniProtKB:Q00535)
42. [Memory Enhancement by Targeting Cdk5 Regulation of NR2B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
43. [Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00535)
44. Ensembl Release 99
45. UMLS 2023