# Cyclin dependent kinase 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5198250](https://www.wikidata.org/wiki/Q5198250)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-4-q5198250


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P11802)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
6. [The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
7. [Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
8. [Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
9. [A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
10. [Cyclin-binding motifs are essential for the function of p21CIP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
11. [A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
12. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
13. [Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
14. [Characterization of VIK-1: a new Vav-interacting Kruppel-like protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
15. [Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
16. [Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
17. [Self-assembling protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
18. [Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
19. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
20. [New functional activities for the p21 family of CDK inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
21. [Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
22. [C-terminal phosphorylation controls the stability and function of p27kip1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
23. [A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
24. [A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
25. [Crystal structure of human CDK4 in complex with a D-type cyclin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
26. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
27. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
28. [Shifted Transversal Design smart-pooling for high coverage interactome mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
29. [Interaction between Cdc37 and Cdk4 in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
30. [The structure of CDK4/cyclin D3 has implications for models of CDK activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
31. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
32. [CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
33. [A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
34. [Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
35. [Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
36. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
37. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
38. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
39. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
40. [RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
41. [Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
42. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
43. [Functional characterization of human PFTK1 as a cyclin-dependent kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
44. [Proteomic analysis of p16ink4a-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
45. [Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
46. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
47. [A directed protein interaction network for investigating intracellular signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
48. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
49. [ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)
50. [A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802)