# Cyclin-dependent kinase 4

> mammalian protein found in Mus musculus

**Wikidata**: [Q14911756](https://www.wikidata.org/wiki/Q14911756)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-4-q14911756


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P30285)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
5. [CDK6 kinase activity is required for thymocyte development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
6. [Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
7. [Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
9. [Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
10. [Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
11. [GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
12. [Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
13. [Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
14. [Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
15. [Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
16. [p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
17. [CDK4 is an essential insulin effector in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
18. [Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
19. [Isolation and characterization of cytoplasmic cyclin D1 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
20. [Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
21. [Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
22. [Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
23. [Requirement for CDK4 kinase function in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
24. [Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
25. [p53 family members in myogenic differentiation and rhabdomyosarcoma development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
26. [Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
27. [Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
28. [Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
29. [The EGF receptor is required for efficient liver regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
30. [Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
31. [Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
33. [C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
34. [Tight function zonula occludens-3 regulates cyclin D1–dependent cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
35. [The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
36. [Gene expression profile analysis of mouse colon embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
37. [C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
38. [Tight function zonula occludens-3 regulates cyclin D1–dependent cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
39. [CDK4 is an essential insulin effector in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
40. [Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
41. [Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
42. [Regulation of the catalytic subunit (p34PSK-J3/cdk4) for the major D-type cyclin in mature B lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
43. [Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
44. [The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
45. [Gene expression profile analysis of mouse colon embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
46. [Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
47. [Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285)
48. [Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
49. [GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285)
50. ensembl Release 106