# Cyclin dependent kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q511968](https://www.wikidata.org/wiki/Q511968)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-2-q511968


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Source](https://www.ebi.ac.uk/intact/interaction/EBI-8617327)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103840)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL445813)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL488436)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL296468)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL564829)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL384304)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545083)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL258805)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1944698)
13. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P24941)
14. Q20641742
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24941&geneProductId=UniProtKB:P24941)
17. [Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24941&geneProductId=UniProtKB:P24941)
18. [Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
19. [Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
20. [Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
21. [Identification and characterization of CAC1 as a novel CDK2-associated cullin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
22. [Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
23. [Overexpression of DOC-1R Inhibits Cell Cycle G1/S Transition by Repressing CDK2 Expression and Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
24. [Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
25. [Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
26. [Human Spy1 promotes survival of mammalian cells following DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
27. [Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
28. [Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
29. [Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
30. [Role of T198 modification in the regulation of p27(Kip1) protein stability and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
31. [Cyclin-binding motifs are essential for the function of p21CIP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
32. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
33. [Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
34. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
35. [Self-assembling protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
36. [Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
37. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
38. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
39. [NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
40. [NIRF induces G1 arrest and associates with Cdk2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
41. [3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
42. [Foxp3 Protein Stability Is Regulated by Cyclin-dependent Kinase 2*](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
43. [C-terminal phosphorylation controls the stability and function of p27kip1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
44. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
45. [Structural basis of cyclin-dependent kinase activation by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
46. [Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
47. [The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
48. [CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
49. [HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)
50. [Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24941)