# cyclin dependent kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q1147372](https://www.wikidata.org/wiki/Q1147372)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_1)  
**Source**: https://4ort.xyz/entity/cyclin-dependent-kinase-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P06493)
4. Q20641742
5. Freebase Data Dumps. 2013
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
7. [The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
8. [Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
9. [Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
10. [The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
11. [Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
12. [Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
13. [The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
14. [Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
15. [Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
16. [Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
17. [Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
18. [cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
19. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
20. [Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
21. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
22. [Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
23. [Simian virus 40 large T antigen affects the Saccharomyces cerevisiae cell cycle and interacts with p34CDC28](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
24. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
25. [Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
26. [A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
27. [CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
28. [A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
29. [RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
30. [Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
31. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
32. [Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
33. [New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
34. [Cell death in leukemia: passenger protein regulation by topoisomerase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
35. [Sulforaphane, a Dietary Isothiocyanate, Induces G₂/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45β/CDC2 Association](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
36. [Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
37. [CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
38. [RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
39. [Comparative Proteomics Reveals Important Viral-Host Interactions in HCV-Infected Human Liver Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
40. [A Novel RNA Polymerase II C-terminal Domain Phosphatase That Preferentially Dephosphorylates Serine 5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
41. [Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
42. [Cyclin A is required at two points in the human cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
43. [Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
44. [Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
45. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493)
46. [Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493)
47. [Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493)
48. [Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06493&geneProductId=UniProtKB:P06493)
49. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)
50. [Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06493)