# Cyclin D1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5198270](https://www.wikidata.org/wiki/Q5198270)  
**Source**: https://4ort.xyz/entity/cyclin-d1


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL189963)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P24385)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385)
6. [INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
7. [Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
8. [Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
10. [NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
11. [F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
12. [Cyclin-binding motifs are essential for the function of p21CIP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
13. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
14. [Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
15. [Self-assembling protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
16. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
17. [New functional activities for the p21 family of CDK inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
18. [Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
19. [A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
20. [Crystal structure of human CDK4 in complex with a D-type cyclin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
21. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
22. [C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
23. [CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
24. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
25. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
26. [Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
27. [Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
28. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
29. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
30. [RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
31. [Isolation and characterization of cytoplasmic cyclin D1 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
32. [Functional characterization of human PFTK1 as a cyclin-dependent kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
33. [Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
34. [Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
35. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
36. [Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
37. [Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385)
38. [Identification of G1 kinase activity for cdk6, a novel cyclin D partner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385)
39. [Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
41. [Identification of G1 kinase activity for cdk6, a novel cyclin D partner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
42. [CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385)
43. [Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385)
44. [CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
45. [Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
46. [Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385)
47. [INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385)
48. [UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
49. [leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385)
50. Ensembl Release 99