# Cyclin D1

> mammalian protein found in Mus musculus

**Wikidata**: [Q15311866](https://www.wikidata.org/wiki/Q15311866)  
**Source**: https://4ort.xyz/entity/cyclin-d1-q15311866


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P25322)
3. Q20641742
4. [Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
6. [GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
7. [Mitotic clonal expansion: a synchronous process required for adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
8. [Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
9. [Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
10. [Tight function zonula occludens-3 regulates cyclin D1–dependent cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
11. [Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
12. [E2F-3B is a physiological target of cyclin A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
13. [Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
14. [Isolation and characterization of cytoplasmic cyclin D1 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
15. [Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
16. [Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
17. [Requirement for CDK4 kinase function in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
18. [Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
19. [Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
20. [The EGF receptor is required for efficient liver regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
21. [Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
22. [Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
23. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
24. [Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
26. [Mitotic clonal expansion: a synchronous process required for adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
27. [Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
28. [Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
29. [The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
30. [CDK4 is an essential insulin effector in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
31. [Patched1 functions as a gatekeeper by promoting cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
32. [Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
33. [Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
34. [Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25322&geneProductId=UniProtKB:P25322)
35. [Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
36. [Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
37. [Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
38. [Patched1 functions as a gatekeeper by promoting cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
39. [The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
40. [Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
41. [CDK4 is an essential insulin effector in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
42. [Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
43. [IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
44. [IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
45. [PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
46. [A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
47. [Impaired mammary gland development in Cyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomous](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
48. [Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
49. [PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)
50. [Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25322)