# Cyclin B1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21131192](https://www.wikidata.org/wiki/Q21131192)  
**Source**: https://4ort.xyz/entity/cyclin-b1


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14635&geneProductId=UniProtKB:P14635)
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
5. [Patched1 interacts with cyclin B1 to regulate cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
6. [Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
7. [Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
8. [Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
9. [Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
10. [NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
11. [cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
12. [Cyclin-binding motifs are essential for the function of p21CIP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
13. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
14. [Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
15. [Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
16. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
17. [Sulforaphane, a Dietary Isothiocyanate, Induces G₂/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45β/CDC2 Association](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
18. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
19. [Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
20. [CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
21. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
22. [Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
23. [The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
24. [A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
25. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
26. [Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
27. [Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
28. [A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
29. [Active cyclin B1-Cdk1 first appears on centrosomes in prophase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14635&geneProductId=UniProtKB:P14635)
30. [Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14635&geneProductId=UniProtKB:P14635)
31. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
32. [Active cyclin B1-Cdk1 first appears on centrosomes in prophase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
33. [Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14635&geneProductId=UniProtKB:P14635)
34. [Patched1 interacts with cyclin B1 to regulate cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14635&geneProductId=UniProtKB:P14635)
35. [Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
36. [The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14635&geneProductId=UniProtKB:P14635)
37. [Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
38. [The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
39. [Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635)
40. [Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14635&geneProductId=UniProtKB:P14635)
41. Ensembl Release 99
42. Transporter Classification database