# Cyclin A2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109659](https://www.wikidata.org/wiki/Q21109659)  
**Source**: https://4ort.xyz/entity/cyclin-a2-q21109659


## References

1. UniProt
2. Q20641742
3. [Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
4. [Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
5. [SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
6. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
7. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
8. [NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
9. [3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
10. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
11. [Structural basis of cyclin-dependent kinase activation by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
12. [Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
13. [Simian virus 40 large T antigen associates with cyclin A and p33cdk2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
14. [Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
15. [Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
16. [Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
17. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
18. [Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
19. [Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
20. [Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
21. [N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
22. [Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
23. [Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
24. [Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
25. [Cyclin A is required at two points in the human cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20248&geneProductId=UniProtKB:P20248)
26. [p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20248&geneProductId=UniProtKB:P20248)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20248&geneProductId=UniProtKB:P20248)
28. [Cyclin A is required at two points in the human cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
29. [p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
32. [mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20248&geneProductId=UniProtKB:P20248)
33. [Structural and functional characterization of the HPV16 E7 protein expressed in bacteria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
34. [The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20248&geneProductId=UniProtKB:P20248)
35. [Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20248&geneProductId=UniProtKB:P20248)
36. [The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
37. [mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
38. [Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
39. [Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
40. [The APC/C inhibitor, Emi1, is essential for prevention of rereplication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248)
41. Ensembl Release 99
42. UMLS 2023