# Cyclic GMP-AMP synthase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q22676633](https://www.wikidata.org/wiki/Q22676633)  
**Source**: https://4ort.xyz/entity/cyclic-gmp-amp-synthase-q22676633


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8N884)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
5. [Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
6. [Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
7. [Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
8. [Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
9. [cGAS surveillance of micronuclei links genome instability to innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
10. [The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
11. [Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
12. [PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
13. [Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N884&geneProductId=UniProtKB:Q8N884)
14. Ensembl Release 99