# Cyclic GMP-AMP synthase

> mammalian protein found in Mus musculus

**Wikidata**: [Q21494203](https://www.wikidata.org/wiki/Q21494203)  
**Source**: https://4ort.xyz/entity/cyclic-gmp-amp-synthase-q21494203


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8C6L5)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
5. [Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
6. [Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
7. [Mitotic progression following DNA damage enables pattern recognition within micronuclei](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
8. [The N terminus of cGAS de‐oligomerizes the cGAS : DNA complex and lifts the DNA size restriction of core‐ cGAS activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
9. [Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
10. [Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
11. [Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
12. [Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
13. [Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C6L5&geneProductId=UniProtKB:Q8C6L5)
14. ensembl Release 106