# Cullin 4A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112920](https://www.wikidata.org/wiki/Q21112920)  
**Source**: https://4ort.xyz/entity/cullin-4a


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL468)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13619)
4. Q20641742
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
7. [A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
8. [COMMD1 (Copper Metabolism MURR1 Domain-containing Protein 1) Regulates Cullin RING Ligases by Preventing CAND1 (Cullin-associated Nedd8-dissociated Protein 1) Binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
9. [NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
10. [Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
11. [CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
12. [UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
13. [NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
14. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
15. [VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
16. [CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
17. [TIP120A associates with cullins and modulates ubiquitin ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
18. [A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
19. [RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
20. [The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
21. [Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
22. [A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
23. [WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
25. [DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
26. [CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
27. [Identification of a Primary Target of Thalidomide Teratogenicity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
28. [Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
29. [The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
30. [PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
31. [Identification of a Primary Target of Thalidomide Teratogenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
32. [The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
33. [CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
34. [DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
35. [PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
36. [WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
37. [cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
38. [Selective degradation of splicing factor CAPERα by anticancer sulfonamides](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619)
39. [Selective degradation of splicing factor CAPERα by anticancer sulfonamides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
40. [CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619)
41. Ensembl Release 99
42. UMLS 2023