Cullin 4A
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P361
  value: winged helix DNA-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Cullin homology domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Winged helix-like DNA-binding domain superfamily
additional property: PropertyValue
  property ID: P527
  value: Cullin homology domain
additional property: PropertyValue
  property ID: P527
  value: Cullin, N-terminal
additional property: PropertyValue
  property ID: P527
  value: Cullin, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_666319
additional property: PropertyValue
  property ID: P637
  value: NP_001350377
additional property: PropertyValue
  property ID: P637
  value: NP_001350379
additional property: PropertyValue
  property ID: P680
  value: ubiquitin protein ligase activity
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: ubiquitin protein ligase binding
additional property: PropertyValue
  property ID: P681
  value: cullin-RING ubiquitin ligase complex
additional property: PropertyValue
  property ID: P681
  value: Cul4-RING E3 ubiquitin ligase complex
additional property: PropertyValue
  property ID: P681
  value: Cul4A-RING E3 ubiquitin ligase complex
additional property: PropertyValue
  property ID: P682
  value: positive regulation of protein catabolic process
additional property: PropertyValue
  property ID: P682
  value: ubiquitin-dependent protein catabolic process
additional property: PropertyValue
  property ID: P682
  value: negative regulation of granulocyte differentiation
additional property: PropertyValue
  property ID: P702
  value: Cul4a
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000016680
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000112525
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000123074
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 17
      unique citations norm: 0.007
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 17
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q3TCH7
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797505
    source count: 1
    confidence: 0.2
    value label: winged helix DNA-binding domain superfamily
  P361:
    value: Q41797435
    source count: 1
    confidence: 0.2
    value label: Cullin homology domain superfamily
  P361:
    value: Q41797502
    source count: 1
    confidence: 0.2
    value label: Winged helix-like DNA-binding domain superfamily
  P361:
    value: Q24787561
    source count: 1
    confidence: 0.2
    value label: Cullin repeat-like-containing domain superfamily
  P361:
    value: Q83164178
    source count: 1
    confidence: 0.2
    value label: Cullin, N-terminal domain, protein family
  P527:
    value: Q24788083
    source count: 1
    confidence: 0.2
    value label: Cullin homology domain
  P527:
    value: Q24784981
    source count: 1
    confidence: 0.2
    value label: Cullin, N-terminal
  P527:
    value: Q24785140
    source count: 1
    confidence: 0.2
    value label: Cullin, conserved site
  P527:
    value: Q24780317
    source count: 1
    confidence: 0.2
    value label: Cullin protein, neddylation domain
  P637:
    value: NP_666319
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001350377
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001350379
    source count: 1
    confidence: 0.2
  P680:
    value: Q21095456
    source count: 1
    confidence: 0.2
    value label: ubiquitin protein ligase activity
  P680:
    value: Q167149
    source count: 2
    confidence: 0.4
    value label: protein binding
  P680:
    value: Q14633869
    source count: 2
    confidence: 0.4
    value label: ubiquitin protein ligase binding
  P681:
    value: Q21101944
    source count: 1
    confidence: 0.2
    value label: cullin-RING ubiquitin ligase complex
  P681:
    value: Q21101017
    source count: 3
    confidence: 0.6
    value label: Cul4-RING E3 ubiquitin ligase complex
  P681:
    value: Q15326411
    source count: 4
    confidence: 0.8
    value label: Cul4A-RING E3 ubiquitin ligase complex
  P681:
    value: Q21101944
    source count: 2
    confidence: 0.4
    value label: cullin-RING ubiquitin ligase complex

value: Q21101017
source count: 4
confidence: 0.8
value label: Cul4-RING E3 ubiquitin ligase complex

value: Q14865069
source count: 1
confidence: 0.2
value label: positive regulation of protein catabolic process

value: Q14864233
source count: 2
confidence: 0.4
value label: ubiquitin-dependent protein catabolic process

value: Q14864029
source count: 1
confidence: 0.2
value label: negative regulation of granulocyte differentiation

value: Q14864652
source count: 1
confidence: 0.2
value label: somatic stem cell population maintenance

value: Q14818001
source count: 1
confidence: 0.2
value label: in utero embryonic development

value: Q18271024
source count: 1
confidence: 0.2
value label: Cul4a

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000016680
source count: 1
confidence: 0.2

value: ENSMUSP00000112525
source count: 1
confidence: 0.2

value: ENSMUSP00000123074
source count: 1
confidence: 0.2

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis
stated in qid: Q28593723
retrieved: 2019-02-14

source: RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly
stated in qid: Q27331221
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors
stated in qid: Q24321702
retrieved: 2019-02-14

source: CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis
stated in qid: Q28508809
retrieved: 2018-03-27

source: Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle
stated in qid: Q28593133
retrieved: 2019-02-14

source: Cul4A is required for hematopoietic stem-cell engraftment and self-renewal
stated in qid: Q28587021
retrieved: 2019-02-14

source: CUL-4A is critical for early embryonic development
stated in qid: Q28594730
retrieved: 2019-02-14

source: CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis
stated in qid: Q28508809
retrieved: 2019-02-14

source: Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis
stated in qid: Q28593723
retrieved: 2018-09-10

source: Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis
stated in qid: Q28593134
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21981698
domain: protein
level: standard
html url: https://4ort.xyz/entity/cullin-4a-q21981698
markdown url: https://4ort.xyz/entity/cullin-4a-q21981698.md
facts url summary: https://4ort.xyz/entity/cullin-4a-q21981698/facts.json
facts url standard: https://4ort.xyz/entity/cullin-4a-q21981698/facts.json
facts url full: https://4ort.xyz/entity/cullin-4a-q21981698/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T14:09:08.600694Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:57:29.049494+00:00Z