# Cullin 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112917](https://www.wikidata.org/wiki/Q21112917)  
**Source**: https://4ort.xyz/entity/cullin-2


## References

1. UniProt
2. [BioGRID](https://thebiogrid.org/news/227)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13617)
4. Q20641742
5. [COMMD1 (Copper Metabolism MURR1 Domain-containing Protein 1) Regulates Cullin RING Ligases by Preventing CAND1 (Cullin-associated Nedd8-dissociated Protein 1) Binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
6. [SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
7. [COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
8. [CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
9. [Global landscape of HIV-human protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
10. [NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
11. [UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
12. [Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
13. [Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
14. [NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
15. [Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
16. [TIP120A associates with cullins and modulates ubiquitin ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
17. [VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
18. [CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13617&geneProductId=UniProtKB:Q13617)
21. [ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13617&geneProductId=UniProtKB:Q13617)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
23. [ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
24. [cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13617)
25. Ensembl Release 99