# Cullin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21101946](https://www.wikidata.org/wiki/Q21101946)  
**Source**: https://4ort.xyz/entity/cullin-1-q21101946


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13616)
3. Q20641742
4. [The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
5. [SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
6. [Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
7. [Myeloma Overexpressed 2 (Myeov2) Regulates L11 Subnuclear Localization through Nedd8 Modification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
8. [Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
9. [NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
10. [COMMD1 (Copper Metabolism MURR1 Domain-containing Protein 1) Regulates Cullin RING Ligases by Preventing CAND1 (Cullin-associated Nedd8-dissociated Protein 1) Binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
11. [Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
12. [NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
13. [Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
14. [FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
15. [F-box protein FBXL19–mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
16. [CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
17. [Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
18. [CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
19. [Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
20. [SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
21. [A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
22. [Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
23. [Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
24. [UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
25. [Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
26. [Characterization of FBX25, encoding a novel brain-expressed F-box protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
27. [Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
28. [CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
29. [Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
30. [Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
31. [Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
32. [The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
33. [Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
34. [Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
35. [Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
36. [Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
37. [NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
38. [Defining the human deubiquitinating enzyme interaction landscape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
39. [TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
40. [FBXW7‐mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
41. [Impaired DNA damage checkpoint response in MIF-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
42. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
43. [Ribosomal proteins are targets for the NEDD8 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
44. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
45. [CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
46. [Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
47. [A High-Density Map for Navigating the Human Polycomb Complexome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
48. [Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
49. [Mediator acts upstream of the transcriptional activator Gal4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)
50. [Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13616)