# Cubitus interruptus Dmel_CG2125

> protein found in Drosophila melanogaster

**Wikidata**: [Q29819808](https://www.wikidata.org/wiki/Q29819808)  
**Source**: https://4ort.xyz/entity/cubitus-interruptus-dmel-cg2125


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P19538)
3. Q20641742
4. [Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
5. [Odd paired transcriptional activation of decapentaplegic in the Drosophila eye/antennal disc is cell autonomous but indirect.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
6. [Odd paired transcriptional activation of decapentaplegic in the Drosophila eye/antennal disc is cell autonomous but indirect.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
7. [Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
9. [Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
10. [Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
11. [A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
12. [Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
13. [Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
14. [The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
15. [Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
16. [Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
17. [A protein interaction map of Drosophila melanogaster](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
18. [Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
19. [Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
20. [A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
21. [Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
22. [Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
23. [The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
24. [Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
25. [Hedgehog targets in theDrosophilaembryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
26. [Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
27. [Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
28. [The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
29. [Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
30. [Sequential phosphorylation of smoothened transduces graded hedgehog signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
31. [Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
32. [The role of segment polarity genes during early oogenesis in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
33. [Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
34. [Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
35. [Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
36. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
37. [The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
38. [Identification of a tetrameric hedgehog signaling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
39. [Suppressor of fused links Fused and Cubitus interruptus on the Hedgehog signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
40. [The role of segment polarity genes during early oogenesis in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
41. [Bacterial Uracil Modulates Drosophila DUOX-Dependent Gut Immunity via Hedgehog-Induced Signaling Endosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
42. [Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
43. [Regulation of Hedgehog signaling: a complex story](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
44. [Selector and signalling molecules cooperate in organ patterning](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
45. [The ihog cell-surface proteins bind Hedgehog and mediate pathway activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
46. [An absolute requirement for Cubitus interruptus in Hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538)
47. [Hedgehog acts as a somatic stem cell factor in the Drosophila ovary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
48. [Conservation of the segmented germband stage: robustness or pleiotropy?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
49. [Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)
50. [The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538)