CST3
type: Thing
description: protein-coding gene in the species Homo sapiens
additional property: PropertyValue
  property ID: P18
  value: Crystal structure of human cystatin C monomer.png
additional property: PropertyValue
  property ID: P31
  value: gene
additional property: PropertyValue
  property ID: P279
  value: protein-coding gene
additional property: PropertyValue
  property ID: P351
  value: 1471
additional property: PropertyValue
  property ID: P353
  value: CST3
additional property: PropertyValue
  property ID: P354
  value: 2475
additional property: PropertyValue
  property ID: P492
  value: 604312
additional property: PropertyValue
  property ID: P593
  value: 78
additional property: PropertyValue
  property ID: P594
  value: ENSG00000101439
additional property: PropertyValue
  property ID: P639
  value: NM_001288614
additional property: PropertyValue
  property ID: P639
  value: NM_000099
additional property: PropertyValue
  property ID: P644
  value: 23626706
additional property: PropertyValue
  property ID: P644
  value: 23608534
additional property: PropertyValue
  property ID: P645
  value: 23638473
additional property: PropertyValue
  property ID: P645
  value: 23619110
additional property: PropertyValue
  property ID: P680
  value: amyloid-beta binding
additional property: PropertyValue
  property ID: P680
  value: protease binding
additional property: PropertyValue
  property ID: P680
  value: endopeptidase inhibitor activity
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: basement membrane
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P682
  value: eye development
additional property: PropertyValue
  property ID: P682
  value: response to hypoxia
additional property: PropertyValue
  property ID: P682
  value: cell activation
additional property: PropertyValue
  property ID: P684
  value: Cst3
additional property: PropertyValue
  property ID: P684
  value: Cst3
additional property: PropertyValue
  property ID: P688
  value: Cystatin C
additional property: PropertyValue
  property ID: P692
  value: PBB GE CST3 201360 at fs.png
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P704
  value: ENST00000398411
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 26
      unique citations norm: 0.01
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 26
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P18:
    value: Crystal structure of human cystatin C monomer.png
    source count: 0
    confidence: 0.0
  P31:
    value: Q7187
    source count: 1
    confidence: 0.2
    value label: gene
  P279:
    value: Q20747295
    source count: 1
    confidence: 0.2
    value label: protein-coding gene
  P351:
    value: 1471
    source count: 1
    confidence: 0.2
  P353:
    value: CST3
    source count: 1
    confidence: 0.2
  P354:
    value: 2475
    source count: 1
    confidence: 0.2
  P492:
    value: 604312
    source count: 1
    confidence: 0.2
  P593:
    value: 78
    source count: 1
    confidence: 0.2
  P594:
    value: ENSG00000101439
    source count: 1
    confidence: 0.2
  P639:
    value: NM_001288614
    source count: 1
    confidence: 0.2
  P639:
    value: NM_000099
    source count: 1
    confidence: 0.2
  P644:
    value: 23626706
    source count: 1
    confidence: 0.2
  P644:
    value: 23608534
    source count: 1
    confidence: 0.2
  P645:
    value: 23638473
    source count: 1
    confidence: 0.2
  P645:
    value: 23619110
    source count: 1
    confidence: 0.2
  P680:
    value: Q14890311
    source count: 1
    confidence: 0.2
    value label: amyloid-beta binding
  P680:
    value: Q14758894
    source count: 3
    confidence: 0.6
    value label: protease binding
  P680:
    value: Q14861841
    source count: 1
    confidence: 0.2
    value label: endopeptidase inhibitor activity
  P680:
    value: Q14762609
    source count: 6
    confidence: 1.0
    value label: cysteine-type endopeptidase inhibitor activity
  P680:
    value: Q167149
    source count: 1
    confidence: 0.2
    value label: protein binding
  P681:
    value: Q14645596
    source count: 3
    confidence: 0.6
    value label: extracellular region

value: Q32846
source count: 1
confidence: 0.2
value label: basement membrane

value: Q1385443
source count: 4
confidence: 0.8
value label: extracellular space

value: Q79899
source count: 1
confidence: 0.2
value label: cytoplasm

value: Q83330
source count: 1
confidence: 0.2
value label: lysosome

value: Q5422650
source count: 1
confidence: 0.2
value label: eye development

value: Q14819239
source count: 1
confidence: 0.2
value label: response to hypoxia

value: Q14819478
source count: 1
confidence: 0.2
value label: cell activation

value: Q14599311
source count: 1
confidence: 0.2
value label: apoptotic process

value: Q14820936
source count: 1
confidence: 0.2
value label: defense response

value: Q14913589
source count: 2
confidence: 0.4
value label: Cst3

value: Q24408309
source count: 2
confidence: 0.4
value label: Cst3

value: Q413243
source count: 1
confidence: 0.2
value label: Cystatin C

value: PBB GE CST3 201360 at fs.png
source count: 0
confidence: 0.0

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENST00000398411
source count: 1
confidence: 0.2

value: ENST00000376925
source count: 1
confidence: 0.2

value: ENST00000398409
source count: 1
confidence: 0.2

value: Q666752
source count: 1
confidence: 0.2
value label: human chromosome 20

value: Q10992004
source count: 1
confidence: 0.2
value label: hereditary cystatin C amyloid angiopathy

value: Q27437074
source count: 1
confidence: 0.2
value label: age related macular degeneration 11

value: Q22809711
source count: 1
confidence: 0.2
value label: reverse strand

value: http://identifiers.org/ncbigene/1471
source count: 1
confidence: 0.2

value: C1413772
source count: 1
confidence: 0.2

value: 20p11.21
source count: 1
confidence: 0.2

value: Q66570450
source count: 1
confidence: 0.2
value label: right frontal lobe

value: Q338924
source count: 1
confidence: 0.2
value label: amygdala

value: Q66502829
source count: 1
confidence: 0.2
value label: right testis

value: Q66502830
source count: 1
confidence: 0.2
value label: left testis

value: Q1476178
source count: 1
confidence: 0.2
value label: nucleus accumbens

source: Cystatin C modulates cerebral beta-amyloidosis
stated in qid: Q24300978
retrieved: 2017-07-18

source: The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors
stated in qid: Q24300962
retrieved: 2017-07-18

source: Structural basis for the biological specificity of cystatin C. Identification of leucine 9 in the N-terminal binding region as a selectivity-conferring residue in the inhibition of mammalian cysteine peptidases
stated in qid: Q24317192
retrieved: 2017-07-18

source: GOA
stated in qid: Q28018111
retrieved: 2017-07-18

source: Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme
stated in qid: Q24338708
retrieved: 2017-07-18

source: Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids
stated in qid: Q24299090
retrieved: 2017-07-18

source: The salivary lipocalin von Ebner's gland protein is a cysteine proteinase inhibitor
stated in qid: Q24314223
retrieved: 2017-07-18

source: The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization
stated in qid: Q24308267
retrieved: 2017-07-18

source: Amyloid properties of the leader peptide of variant B cystatin C: implications for Alzheimer and macular degeneration
stated in qid: Q28118595
retrieved: 2017-07-18

source: Human colostrum: identification of minor proteins in the aqueous phase by proteomics
stated in qid: Q24305934
retrieved: 2017-07-18

source: Serum cystatin C level for better assessment of glomerular filtration rate in cystic fibrosis patients treated by amikacin
stated in qid: Q24311390
retrieved: 2017-07-18

source: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
stated in qid: Q24308771
retrieved: 2017-07-18

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2017-07-18

source: Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
stated in qid: Q24313258
retrieved: 2017-07-18

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2017-07-18

source: Cystatin C deficiency in human atherosclerosis and aortic aneurysms
stated in qid: Q22010733
retrieved: 2017-07-18

source: Bgee
stated in qid: Q54985720
retrieved: 2024-06-07

source: Orthologous MAtrix
stated in qid: Q7104801

source: Identifiers.org
stated in qid: Q16335166

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-05-15

source: Online Mendelian Inheritance in Man
stated in qid: Q241953
retrieved: 2019-08-19

source: UniProt
stated in qid: Q905695
retrieved: 2017-03-16

source: UMLS 2023
stated in qid: Q118645236
retrieved: 2023-06-15

source: ensembl Release 106
stated in qid: Q111699881

source: Ensembl Release 87
stated in qid: Q27975061

source: HomoloGene build68
stated in qid: Q20976936

wikidata id: Q14913588
domain: gene
level: standard
html url: https://4ort.xyz/entity/cst3-q14913588
markdown url: https://4ort.xyz/entity/cst3-q14913588.md
facts url summary: https://4ort.xyz/entity/cst3-q14913588/facts.json
facts url standard: https://4ort.xyz/entity/cst3-q14913588/facts.json
facts url full: https://4ort.xyz/entity/cst3-q14913588/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T00:53:04.344896Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:10:40.945259+00:00Z