# Crystallin, alpha A

> mammalian protein found in Mus musculus

**Wikidata**: [Q21173266](https://www.wikidata.org/wiki/Q21173266)  
**Source**: https://4ort.xyz/entity/crystallin-alpha-a-q21173266


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P24622)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
5. [Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
6. [Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
7. [Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
8. [Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
9. [The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
10. [Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
11. [Alpha-crystallin expression affects microtubule assembly and prevents their aggregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
12. [Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
13. [Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
14. [Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
15. [Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
16. [Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
17. [Chromosomal localization of a new mouse lens opacity gene (lop18)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
18. [alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622)
19. ensembl Release 106