# Cryptochrome 2 (photolyase-like)

> mammalian protein found in Mus musculus

**Wikidata**: [Q21499186](https://www.wikidata.org/wiki/Q21499186)  
**Source**: https://4ort.xyz/entity/cryptochrome-2-photolyase-like-


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9R194)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
5. [SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
6. [A Molecular Mechanism for Circadian Clock Negative Feedback](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
7. [Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
8. [Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
9. [CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
10. [Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
11. [A Novel Protein, CHRONO, Functions as a Core Component of the Mammalian Circadian Clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
12. [Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
13. [USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
14. [FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
15. [A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
16. [The Polycomb Group Protein EZH2 Is Required for Mammalian Circadian Clock Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
17. [Direct Association between Mouse PERIOD and CKIε Is Critical for a Functioning Circadian Clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
18. [Identification of two Amino Acids in the C-terminal Domain of Mouse CRY2 Essential for PER2 Interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
19. [Importin α/β Mediates Nuclear Transport of a Mammalian Circadian Clock Component, mCRY2, Together with mPER2, through a Bipartite Nuclear Localization Signal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
20. [Machine Learning Helps Identify CHRONO as a Circadian Clock Component](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
21. [Cryptochromes mediate rhythmic repression of the glucocorticoid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
22. [Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
23. [CAVIN‐3 regulates circadian period length and PER:CRY protein abundance and interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
24. [CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
25. [Dynamic Circadian Protein–Protein Interaction Networks Predict Temporal Organization of Cellular Functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
26. [DYRK1A and Glycogen Synthase Kinase 3β, a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
27. [Characterization of photolyase/blue-light receptor homologs in mouse and human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9R194&geneProductId=UniProtKB:Q9R194)
29. [Preferential Inhibition of BMAL2-CLOCK Activity by PER2 Reemphasizes Its Negative Role and a Positive Role of BMAL2 in the Circadian Transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
30. [High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry -deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
31. [Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
32. [Distinct and Separable Roles for Endogenous CRY1 and CRY2 within the Circadian Molecular Clockwork of the Suprachiasmatic Nucleus, as Revealed by the Fbxl3 Afh Mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
33. [Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
34. [Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
35. [CIPC is a mammalian circadian clock protein without invertebrate homologues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
36. [Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
37. [Histone Acetyltransferase-dependent Chromatin Remodeling and the Vascular Clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
38. [Differential roles for cryptochromes in the mammalian retinal clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
39. [Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
40. [LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194)
41. ensembl Release 106