# CRK proto-oncogene, adaptor protein

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558126](https://www.wikidata.org/wiki/Q28558126)  
**Source**: https://4ort.xyz/entity/crk-proto-oncogene-adaptor-protein


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q63768)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
5. [TGF-β1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
6. [Grit, a GTPase-Activating Protein for the Rho Family, Regulates Neurite Extension through Association with the TrkA Receptor and N-Shc and CrkL/Crk Adapter Molecules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
7. [Abl Silencing Inhibits CAS-Mediated Process and Constriction in Resistance Arteries](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
8. [Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini. Formation of CrkII-protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
9. [Adapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
10. [Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
11. [Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
12. [Evidence for Functional Roles of Crk-II in Insulin and Epidermal Growth Factor Signaling in Rat-1 Fibroblasts Overexpressing Insulin Receptors*](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
13. [Differential Regulation of Cell Migration, Actin Stress Fiber Organization, and Cell Transformation by Functional Domains of Crk-associated Substrate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
14. [CrkII signals from epidermal growth factor receptor to Ras.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
15. [p130Cas, Crk-Associated Substrate Plays Essential Roles in Liver Development by Regulating Sinusoidal Endothelial Cell Fenestration†](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
16. [Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
17. [Transduction pathways regulating the trophic effects ofSaccharomyces boulardiiin rat intestinal mucosa](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
18. [Nitric oxide-induced inhibition of aortic smooth muscle cell motility: role of PTP-PEST and adaptor proteins p130cas and Crk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
19. [Tyrosine 221 in Crk regulates adhesion‐dependent membrane localization of Crk and Rac and activation of Rac signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
20. [Inhibitory Receptor Signaling via Tyrosine Phosphorylation of the Adaptor Crk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
21. [Selective Involvement of p130Cas/Crk/Pyk2/c-Src in Endothelin-1-Induced JNK Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63768)
22. ensembl Release 106