# CRK like proto-oncogene, adaptor protein

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21104798](https://www.wikidata.org/wiki/Q21104798)  
**Source**: https://4ort.xyz/entity/crk-like-proto-oncogene-adaptor-protein


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P46109)
3. Q20641742
4. [DOCK5 and DOCK1 Regulate Caco-2 Intestinal Epithelial Cell Spreading and Migration on Collagen IV](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
5. [The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
6. [Identification of Tyr-762 in the platelet-derived growth factor α-receptor as the binding site for Crk proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
7. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
8. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
9. [Characterization of p87C3G, a novel, truncated C3G isoform that is overexpressed in chronic myeloid leukemia and interacts with Bcr-Abl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
10. [A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
11. [Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
12. [A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
13. [Phospho‐tyrosine dependent protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
14. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
15. [Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
16. [An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
17. [Analysis of Protein-Protein Interactions in Cross-talk Pathways Reveals CRKL Protein as a Novel Prognostic Marker in Hepatocellular Carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
18. [Enhanced Prediction of Src Homology 2 (SH2) Domain Binding Potentials Using a Fluorescence Polarization-derived c-Met, c-Kit, ErbB, and Androgen Receptor Interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
19. [Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
20. [Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
21. [ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
22. [Identification of a Switch in Neurotrophin Signaling by Selective Tyrosine Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
23. [BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
24. [The CRKL Adaptor Protein Transforms Fibroblasts and Functions in Transformation by the BCR-ABL Oncogene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46109&geneProductId=UniProtKB:P46109)
25. [Isolation and chromosomal localization of CRKL, a human crk-like gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46109&geneProductId=UniProtKB:P46109)
26. [Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46109&geneProductId=UniProtKB:P46109)
27. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46109&geneProductId=UniProtKB:P46109)
28. [Tarp regulates earlyChlamydia-induced host cell survival through interactions with the human adaptor protein SHC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
29. [The C-Terminal SH3 Domain of CRKL as a Dynamic Dimerization Module Transiently Exposing a Nuclear Export Signal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
30. [Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
31. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
32. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46109&geneProductId=UniProtKB:P46109)
33. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46109&geneProductId=UniProtKB:P46109)
34. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
35. [The CRKL Adaptor Protein Transforms Fibroblasts and Functions in Transformation by the BCR-ABL Oncogene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
36. [Isolation and chromosomal localization of CRKL, a human crk-like gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
37. [Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
38. [Crkl Efficiently Mediates Cell Proliferation, Migration, and Invasion Induced by TGF-β Pathway in Glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109)
39. Ensembl Release 99
40. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)