# Costa Dmel_CG1708

> protein found in Drosophila melanogaster

**Wikidata**: [Q29821017](https://www.wikidata.org/wiki/Q29821017)  
**Source**: https://4ort.xyz/entity/costa-dmel-cg1708


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O16844)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
5. [Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
6. [Flying through the drosophila cytoskeletal genome.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
8. [Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
9. [Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
10. [Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
11. [Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
12. [Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
13. [G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
14. [PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
15. [The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
16. [Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
17. [The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
18. [A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
19. [Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
20. [The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
21. [Costal 2 interactions with Cubitus interruptus (Ci) underlying Hedgehog-regulated Ci processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
22. [Flying through the drosophila cytoskeletal genome.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
24. [Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
25. [The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
26. [Identification of a tetrameric hedgehog signaling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
27. [The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
28. [Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
29. [Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
30. [Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
31. [Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
32. [Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
33. [Cilia-mediated hedgehog signaling in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
34. [Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
35. [Regulation of Hedgehog signaling: a complex story](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
36. [Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
37. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
38. [Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
39. [Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
40. [Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
41. [Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
42. [Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
43. [Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus](http://www.ebi.ac.uk/QuickGO/annotations?protein=O16844&geneProductId=UniProtKB:O16844)
44. [Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
45. [Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
46. [Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
47. [The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O16844)
48. ensembl Release 106