# Cortactin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5173210](https://www.wikidata.org/wiki/Q5173210)  
**Source**: https://4ort.xyz/entity/cortactin-q5173210


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14247)
3. Q20641742
4. [The association of cortactin with profilin-1 is critical for smooth muscle contraction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
5. [Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
6. [Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
7. [Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
8. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
9. [PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
10. [A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
11. [Distinct phosphorylation requirements regulate cortactin activation by TirEPEC and its binding to N-WASP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
12. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
13. [Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
14. [Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
15. [Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
16. [Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
17. [Functional specialization of beta-arrestin interactions revealed by proteomic analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
18. [CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
19. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14247&geneProductId=UniProtKB:Q14247)
20. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
22. [The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
23. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14247&geneProductId=UniProtKB:Q14247)
24. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14247&geneProductId=UniProtKB:Q14247)
25. [Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
26. [RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
27. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14247&geneProductId=UniProtKB:Q14247)
28. [The redistribution of cortactin into cell-matrix contact sites in human carcinoma cells with 11q13 amplification is associated with both overexpression and post-translational modification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
29. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
30. [An essential role for cortactin in the modulation of the potassium channel Kv1.2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14247)
31. ensembl Release 96
32. Identifiers.org