# Cortactin

> mammalian protein found in Mus musculus

**Wikidata**: [Q14906157](https://www.wikidata.org/wiki/Q14906157)  
**Source**: https://4ort.xyz/entity/cortactin-q14906157


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q60598)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
5. [Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
6. [Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
7. [A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
8. [Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
9. [A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
10. [Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
11. [Cortactin regulates cell migration through activation of N-WASP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
12. [Src phosphorylation of cortactin enhances actin assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
13. [Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
14. [Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
15. [Activation of Arp2/3 complex-mediated actin polymerization by cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
16. [Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
17. [p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
18. [Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
19. [Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
20. [Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
21. [Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
22. [Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
23. [An essential role for cortactin in the modulation of the potassium channel Kv1.2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60598&geneProductId=UniProtKB:Q60598)
25. [Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
26. [WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
27. [Src-dependent phosphorylation of ASAP1 regulates podosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
28. [F-box protein FBXL19–mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
29. [Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
30. [Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60598)
31. ensembl Release 106