# Component of inhibitor of nuclear factor kappa B kinase complex

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130508](https://www.wikidata.org/wiki/Q21130508)  
**Source**: https://4ort.xyz/entity/component-of-inhibitor-of-nuclear-factor-kappa-b-kinase-complex


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O15111)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
6. [NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
7. [The IkappaB kinase complex: master regulator of NF-kappaB signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15111&geneProductId=UniProtKB:O15111)
8. [A cytokine-responsive IκB kinase that activates the transcription factor NF-κB](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15111&geneProductId=UniProtKB:O15111)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15111&geneProductId=UniProtKB:O15111)
10. [The Zinc Finger Protein ZNF268 Is Overexpressed in Human Cervical Cancer and Contributes to Tumorigenesis via Enhancing NF-κB Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
11. [SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
12. [Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
13. [IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
14. [Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
15. [LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
16. [Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
17. [IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
18. [TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
19. [Binding of manumycin A inhibits IkappaB kinase beta activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
20. [Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
21. [A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
22. [A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
23. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
24. [The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
25. [betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
26. [Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
27. [The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
28. [Hepatitis B Virus Polymerase Suppresses NF-κB Signaling by Inhibiting the Activity of IKKs via Interaction with Hsp90β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
29. [A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
30. [IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
31. [The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
32. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
33. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
34. [Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
35. [Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
36. [IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
37. [IκB kinases increase Myc protein stability and enhance progression of breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
38. [IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
39. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
40. [Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
41. [A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
42. [Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
43. [Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
44. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
45. [Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
46. [A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
47. [Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
48. [NF-κB signalling is attenuated by the E7 protein from cutaneous human papillomaviruses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
49. [Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)
50. [Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15111)