Complement C4A
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P08649
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin-like fold
additional property: PropertyValue
  property ID: P361
  value: Tissue inhibitor of metalloproteinases-like, OB-fold
additional property: PropertyValue
  property ID: P361
  value: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
additional property: PropertyValue
  property ID: P527
  value: Alpha-macroglobulin, receptor-binding
additional property: PropertyValue
  property ID: P527
  value: Alpha-2-macroglobulin, bait region domain
additional property: PropertyValue
  property ID: P527
  value: Anaphylatoxin/fibulin
additional property: PropertyValue
  property ID: P637
  value: NP_113692
additional property: PropertyValue
  property ID: P680
  value: molecular function
additional property: PropertyValue
  property ID: P680
  value: endopeptidase inhibitor activity
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P681
  value: cell junction
additional property: PropertyValue
  property ID: P682
  value: immune system process
additional property: PropertyValue
  property ID: P682
  value: inflammatory response
additional property: PropertyValue
  property ID: P682
  value: complement activation
additional property: PropertyValue
  property ID: P702
  value: C4a
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000066721
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000068572
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000069352
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 9
      unique citations norm: 0.004
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 9
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P08649
    source count: 1
    confidence: 0.2
  P361:
    value: Q24787648
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like fold
  P361:
    value: Q24723575
    source count: 1
    confidence: 0.2
    value label: Tissue inhibitor of metalloproteinases-like, OB-fold
  P361:
    value: Q24778163
    source count: 1
    confidence: 0.2
    value label: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
  P361:
    value: Q24782797
    source count: 1
    confidence: 0.2
    value label: Anaphylatoxin, complement system
  P361:
    value: Q43921642
    source count: 1
    confidence: 0.2
    value label: Complement component C4-A
  P527:
    value: Q24725003
    source count: 1
    confidence: 0.2
    value label: Alpha-macroglobulin, receptor-binding
  P527:
    value: Q24770317
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin, bait region domain
  P527:
    value: Q24741170
    source count: 1
    confidence: 0.2
    value label: Anaphylatoxin/fibulin
  P527:
    value: Q24769303
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin
  P527:
    value: Q24739870
    source count: 1
    confidence: 0.2
    value label: Anaphylatoxin, complement system domain
  P637:
    value: NP_113692
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860489
    source count: 1
    confidence: 0.2
    value label: molecular function
  P680:
    value: Q14861841
    source count: 1
    confidence: 0.2
    value label: endopeptidase inhibitor activity
  P681:
    value: Q14645596
    source count: 3
    confidence: 0.6
    value label: extracellular region
  P681:
    value: Q1385443
    source count: 2
    confidence: 0.4
    value label: extracellular space
  P681:
    value: Q189073
    source count: 1
    confidence: 0.2
    value label: cell junction
  P681:
    value: Q178999
    source count: 1
    confidence: 0.2
    value label: axon
  P681:
    value: Q12821248
    source count: 1
    confidence: 0.2
    value label: dendrite
  P682:
    value: Q14916317
    source count: 1
    confidence: 0.2
    value label: immune system process
  P682:
    value: Q14819849
    source count: 2
    confidence: 0.4
    value label: inflammatory response

value: Q14864930
source count: 2
confidence: 0.4
value label: complement activation

value: Q5128320
source count: 1
confidence: 0.2
value label: complement activation, classical pathway

value: Q14859614
source count: 1
confidence: 0.2
value label: negative regulation of endopeptidase activity

value: Q24394750
source count: 1
confidence: 0.2
value label: C4a

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000066721
source count: 1
confidence: 0.2

value: ENSRNOP00000068572
source count: 1
confidence: 0.2

value: ENSRNOP00000069352
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Complement C4 protein expression by rat hepatic stellate cells
stated in qid: Q28571077
retrieved: 2019-05-09

source: The rat expresses two complement factor C4 proteins, but only one isotype is expressed in the liver
stated in qid: Q28579394
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)
stated in qid: Q28214372
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2021-11-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2021-09-07

source: ensembl Release 104
stated in qid: Q106833387

wikidata id: Q28559113
domain: protein
level: standard
html url: https://4ort.xyz/entity/complement-c4a
markdown url: https://4ort.xyz/entity/complement-c4a.md
facts url summary: https://4ort.xyz/entity/complement-c4a/facts.json
facts url standard: https://4ort.xyz/entity/complement-c4a/facts.json
facts url full: https://4ort.xyz/entity/complement-c4a/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T03:33:28.196554Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:26:41.845951+00:00Z