# Complement C1r

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111742](https://www.wikidata.org/wiki/Q21111742)  
**Source**: https://4ort.xyz/entity/complement-c1r


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P00736)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
6. [Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736)
8. [Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736)
9. [The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736)
10. [X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
11. [Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
12. [Ca2+ binding properties and Ca2(+)-dependent interactions of the isolated NH2-terminal alpha fragments of human complement proteases C1-r and C1-s](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
13. [Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
15. [The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
16. [The human plasma proteome: a nonredundant list developed by combination of four separate sources](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
17. [Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736)
18. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736)
19. [Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736)
20. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
21. [Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
22. [Familial deficiency of two subunits of the first component of complement. C1r and C1s associated with a lupus erythematosus-like disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736)
23. ensembl Release 96
24. UMLS 2023