# Combining Cloud-Based Free-Energy Calculations, Synthetically Aware Enumerations, and Goal-Directed Generative Machine Learning for Rapid Large-Scale Chemical Exploration and Optimization

> Research article (Journal of Chemical Information and Modeling, 2020) · cited 55× · AI/ML

**Wikidata**: [openalex:W3029978182](https://www.wikidata.org/wiki/openalex:W3029978182)  
**Source**: https://4ort.xyz/entity/combining-cloud-based-free-energy-calculations-synthetically-aware-enumerations-and-goal-directed-generative-machine-lea