# Collagen type V alpha 1 chain

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5145890](https://www.wikidata.org/wiki/Q5145890)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Collagen,_type_V,_alpha_1)  
**Source**: https://4ort.xyz/entity/collagen-type-v-alpha-1-chain


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2095222)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P20908)
4. Q20641742
5. [UniProt](http://www.uniprot.org/uniprot/P20908.txt?172)
6. [Swiss-Prot](http://www.uniprot.org/uniprot/P20908.txt?version=174)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
9. [Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
10. [Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
11. [The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
12. [Primary structure of the heparin-binding site of type V collagen](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
14. [Identification of binding partners interacting with the α1-N-propeptide of type V collagen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
15. [Primary structure of the heparin-binding site of type V collagen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
16. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
17. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
18. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
19. [Proteomics characterization of extracellular space components in the human aorta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
20. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
21. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
22. [Proteomics characterization of extracellular space components in the human aorta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
23. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
24. [Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
25. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
26. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
27. [Mutations in the COL5A1 gene are causal in the Ehlers-Danlos syndromes I and II](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
28. [A Point Mutation in an Intronic Branch Site Results in Aberrant Splicing of COL5A1 and in Ehlers-Danlos Syndrome Type II in Two British Families](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
29. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
30. [Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
31. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
32. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
33. [Mutations in the COL5A1 gene are causal in the Ehlers-Danlos syndromes I and II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
34. [A Point Mutation in an Intronic Branch Site Results in Aberrant Splicing of COL5A1 and in Ehlers-Danlos Syndrome Type II in Two British Families](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
35. [Structural abnormalities of the cornea and lid resulting from collagen V mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
36. [Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
37. [Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
38. [Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
39. [COL5A1 exon 14 splice acceptor mutation causes a functional null allele, haploinsufficiency of alpha 1(V) and abnormal heterotypic interstitial fibrils in Ehlers-Danlos syndrome II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
40. [Reduced type I collagen utilization: a pathogenic mechanism in COL5A1 haplo-insufficient Ehlers-Danlos syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
41. [The COL5A1 gene and Achilles tendon pathology](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
42. [Reduced type I collagen utilization: a pathogenic mechanism in COL5A1 haplo-insufficient Ehlers-Danlos syndrome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
43. [COL5A1 exon 14 splice acceptor mutation causes a functional null allele, haploinsufficiency of alpha 1(V) and abnormal heterotypic interstitial fibrils in Ehlers-Danlos syndrome II](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20908&geneProductId=UniProtKB:P20908)
44. [The COL5A1 gene and Achilles tendon pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20908)
45. Ensembl Release 99
46. Identifiers.org