# Collagen type III alpha 1 chain

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5145885](https://www.wikidata.org/wiki/Q5145885)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Collagen,_type_III,_alpha_1)  
**Source**: https://4ort.xyz/entity/collagen-type-iii-alpha-1-chain


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2095222)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P02461)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
6. [Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
7. [Simple collagen-like peptides support platelet adhesion under static but not under flow conditions: interaction via alpha2 beta1 and von Willebrand factor with specific sequences in native collagen is a requirement to resist shear forces](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
8. [Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
9. [A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
10. [Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
11. [Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
12. [Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
13. [Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
14. [Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
16. [MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
17. [Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
18. [Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
20. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
21. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
22. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
23. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
24. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
25. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
26. [Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
27. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
28. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
29. [G to T transversion at position +5 of a splice donor site causes skipping of the preceding exon in the type III procollagen transcripts of a patient with Ehlers-Danlos syndrome type IV](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
30. [RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
31. [MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
32. [Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
33. [Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
34. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461)
35. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
36. [G to T transversion at position +5 of a splice donor site causes skipping of the preceding exon in the type III procollagen transcripts of a patient with Ehlers-Danlos syndrome type IV](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
37. [RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
38. [Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
39. [Transforming growth factor-beta1-induced hypertrophy and matrix expression in human bladder smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
40. [Interferon-gamma regulates collagen and fibronectin gene expression by transcriptional and post-transcriptional mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
41. [Myocardial infarction resulting from coronary artery dissection in an adolescent with Ehlers-Danlos syndrome type IV due to a type III collagen mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
42. [The effects of single doses of beta radiation on the wound healing behaviour of human Tenon's capsule fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
43. [Collagen types I and III propeptides as markers of healing in chronic leg ulcers. A noninvasive method for the determination of procollagen propeptides in wound fluid--influence of growth hormone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461)
44. Ensembl Release 99
45. Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial
46. Collagenase clostridium histolyticum for the treatment of Peyronie's disease: a prospective Italian multicentric study
47. Collagenase injections for Dupuytren's contracture: prospective cohort study in a public health setting
48. Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases.
49. Identifiers.org